Tox assays

Type:

Acute toxicity

Checks: Lethality and deviations from normality

Variables: Coagulation, heartbeat, tail malformations and lack of somites

Delivery: LC50 is calculated based on the test

Type:

Behavioral toxicity

Checks: Movement patterns

Variables: Swim velocity, light-dark responses, circadian mobility rythms, sleep-wake parameters

Delivery: Detailed plot of circadian rythmicity, responses to light-dark stimuli and sleep-wake
parameters for each tested compound

Type:

Cardiovascular toxicity

Checks: Cardiovascular activity

Variables: Heart rate, rythmicity and blood circulation

Delivery: Detailed plot of dose response concentrations for each tested compound

Type:

Developmental toxicity

Checks: Morphological variations

Variables: Head, tail, trunk, heart, eyes, circulation, fins and mobility

Delivery: LC50 and % of fish showing developmental defects

Type:

Neurotoxicity

We have implemented a wide array of staining protocols using fluorescent and confocal imaging at our facilities, including TH staining for dopamine cells, and acH receptor staining at neuromuscular junctions.

With our expertise and equipment we can custom design a tox assay to address your specific research question at any time.

Contact


3Z ehf.
Menntavegur 1
101 Reykjavik
Iceland
tel.: +354-599-6434
email: info (at) 3z.is