Method

3Z´s method consists of parallel screening of compounds in a sample of ~2500 zebrafish larvae.

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Partners

3Z has partners across a broad area of life sciences and pharmaceutical industry.

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Publications

3Z staff has published a number of scientific papers in academic journals

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Epilepsy assay

3Z Epilepsy assay slide deck is available for download

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Sleep assay

3Z Sleep assay slide deck is now available for download

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3Z – expediting CNS drug discovery

The method developed by 3Z combines the cost efficiency and efficacy of in-vitro tests with the high information content of in vivo testing.

3Z is a preclinical drug company focusing on the discovery of Central Nervous System (CNS) drugs. It provides pharmaceutical companies with expert services in high throughput screening of small molecule libraries for CNS effects.
By automatically monitoring behavior in thousands of zebrafish larvae over 24 hours, using custom built data analysis routines, 3Z can quickly and cost effectively screen thousands of compounds in vivo, significantly reducing the cost and time of CNS drug discovery.
 

Latest 3Z News

Recent publication in Behavioral Brain research

Our team just published a paper on REM sleep in zebrafish. Eye movements and respiratory rate were analysed in adult zebrafish during lights-off and lights-on periods. Read more here.

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Publication in Frontiers in Neural Circuits

3Z´s scientists recently published the paper “The ontogeny of sleep-wake cycles in zebrafish: a comparison to humans” in Frontiers in Neural Circuits. In this paper the development of sleep-wake dynamics and sleep and wake bout structure over the lifespan in zebrafish, including a comparison to humans and other mammals studied thus far, is delineated.read more

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3Z and PCI Synthesis enter research alliance

3Z and PCI Synthesis have entered a research collaboration. This entails 3Z´s screening of PCI´s molecular library of CNS active compounds for sleep-wake effects. Any positive findings will be filed for joint patent applications. PCI´s webpage

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